NK 314

NK 314 is an inhibitor for topoisomerase IIα, which generates the break of DNA double-strand. NK 314 arrests the cell cycle at G2 phase in human acute myeloid leukemia cells, inhibits the proliferation of CEM with IC90 of 55 nM[1].

Product Specifications

CAS Number

[208237-49-4]

UNSPSC

12352005

Target

Topoisomerase

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/nk-314.html

Smiles

OC1=C(C=CC2=C1C(CCC3)=[N+]3C4=C5C=C6OCOC6=CC5=CC=C24)OC.[Cl-]

Molecular Formula

C22H18ClNO4

Molecular Weight

395.84

References & Citations

[1]Guo L, et al., Inhibition of topoisomerase IIalpha and G2 cell cycle arrest by NK314, a novel benzo[c]phenanthridine currently in clinical trials. Mol Cancer Ther. 2007 May;6 (5) :1501-8.