NK 314
Product Specifications
UNSPSC Description
NK 314 is an inhibitor for topoisomerase IIα, which generates the break of DNA double-strand. NK 314 arrests the cell cycle at G2 phase in human acute myeloid leukemia cells, inhibits the proliferation of CEM with IC90 of 55 nM[1].
Target Antigen
Topoisomerase
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/nk-314.html
Smiles
OC1=C(C=CC2=C1C(CCC3)=[N+]3C4=C5C=C6OCOC6=CC5=CC=C24)OC.[Cl-]
Molecular Weight
395.84
References & Citations
[1]Guo L, et al., Inhibition of topoisomerase IIalpha and G2 cell cycle arrest by NK314, a novel benzo[c]phenanthridine currently in clinical trials. Mol Cancer Ther. 2007 May;6(5):1501-8.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-18626/NK-314-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-18626/
Clinical Information
No Development Reported
CAS Number
208237-49-4
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