Brophenexin (free base)
Brophenexin free base (compound 8) is a potent NMDAR/TRPM4 interaction interface inhibitor. Brophenexin free base shows neuroprotective activity. Brophenexin free base prevents NMDA-induced cell death and mitochondrial dysfunction in hippocampal neurons, with an IC50 of 2.1 μM. Brophenexin free base protects mice from MCAO-induced brain damage and NMDA-induced retinal ganglion cell loss[1].
Product Specifications
CAS Number
[1353979-43-7]
Product Name Alternative
NMDAR/TRPM4-IN-2 (free base)
UNSPSC
12352005
Hazard Statement
H302, H314, H335
Target
ERK; iGluR; TRP Channel
Type
Reference compound
Related Pathways
MAPK/ERK Pathway; Membrane Transporter/Ion Channel; Neuronal Signaling; Stem Cell/Wnt
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/nmdar-trpm4-in-2-free-base.html
Concentration
10mM
Purity
99.24
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
NCCN(CC1=CC=CC(Br)=C1)CC
Molecular Formula
C11H17BrN2
Molecular Weight
257.18
Precautions
H302, H314, H335
References & Citations
[1]Yan J, et al. Coupling of NMDA receptors and TRPM4 guides discovery of unconventional neuroprotectants. Science. 2020 Oct 9;370 (6513) :eaay3302.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
NMDA Receptor
Available Sizes
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