Nicastrin Antibody (High Specificity)

<strong>Nicastrin Antibody (High Specificity)</strong>_x000D_ <strong>Catalog number:</strong> B2010561_x000D_ <strong>Lot number:</strong> Batch Dependent_x000D_ <strong>Expiration Date:</strong> Batch dependent_x000D_ <strong>Amount:</strong> 100 uL_x000D_ <strong>Molecular Weight or Concentration:</strong> 150 kDa_x000D_ <strong>Supplied as:</strong> Ascites fluid_x000D_ <strong>Applications:</strong> molecular tool in the study of Nicastrin_x000D_ <strong>Storage:</strong> -20C_x000D_ <strong>Keywords:</strong> Anti-Nicastrin Antibody_x000D_ <strong>Grade:</strong> Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity &gt;18 MΩ-cm) and are filtered through 0.22 um._x000D_ _x000D_ <strong>References:</strong>_x000D_ 1: Hsu CH, Liou GG, Jiang YJ. Nicastrin Deficiency Induces Tyrosinase-Dependent_x000D_ Depigmentation and Skin Inflammation. J Invest Dermatol. 2020_x000D_ Feb;140(2):404-414.e13._x000D_ _x000D_ 2: De Strooper B. Nicastrin: gatekeeper of the gamma-secretase complex. Cell._x000D_ 2005 Aug 12;122(3):318-20._x000D_ _x000D_ 3: Xiao XM, Yang WZ, Lin LH, Li CR. Two novel nicastrin mutations in Chinese_x000D_ families with acne inversa. J Dermatol. 2020 Dec;47(12):e449-e451._x000D_ _x000D_ 4: Garcovich S, Tricarico PM, Nait-Meddour C, Giovanardi G, Peris K, Crovella S,_x000D_ Boniotto M. Novel nicastrin mutation in hidradenitis suppurativa-Dowling-Degos_x000D_ disease clinical phenotype: more than just clinical overlap? Br J Dermatol. 2020_x000D_ Oct;183(4):758-759._x000D_ _x000D_ 5: Nishimura M. [Nicastrin]. Nihon Rinsho. 2011 Oct;69 Suppl 8:115-8. Japanese._x000D_ _x000D_ 6: Choi JH, Han J, Theodoropoulos PC, Zhong X, Wang J, Medler D, Ludwig S, Zhan_x000D_ X, Li X, Tang M, Gallagher T, Yu G, Beutler B. Essential requirement for_x000D_ nicastrin in marginal zone and B-1 B cell development. Proc Natl Acad Sci U S A._x000D_ 2020 Mar 3;117(9):4894-4901._x000D_ _x000D_ 7: Arai MA, Akamine R, Tsuchiya A, Yoneyama T, Koyano T, Kowithayakorn T,_x000D_ Ishibashi M. The Notch inhibitor cowanin accelerates nicastrin degradation. Sci_x000D_ Rep. 2018 Mar 29;8(1):5376._x000D_ _x000D_ 8: Hsu CH, Jiang YJ. Does Nicastrin Inadequacy Cause Melanocytotoxicity in Human_x000D_ Skin as in the Fish Counterpart? J Invest Dermatol. 2021 May;141(5):1334-1338._x000D_ _x000D_ 9: He Y, Xu H, Li C, Zhang X, Zhou P, Xiao X, Zhang W, Wu Y, Zeng R, Wang B._x000D_ Nicastrin/miR-30a-3p/RAB31 Axis Regulates Keratinocyte Differentiation by_x000D_ Impairing EGFR Signaling in Familial Acne Inversa. J Invest Dermatol. 2019_x000D_ Jan;139(1):124-134._x000D_ <a href="https://pubmed.ncbi.nlm.nih.gov/26811479/">10: Urban S. Nicastrin guards Alzheimer's gate. Proc Natl Acad Sci U S A. 2016_x000D_ Feb 2;113(5):1112-4. </a>_x000D_ _x000D_ <strong>Products Related to Nicastrin Antibody (High Specificity)</strong> <a href="https://moleculardepot.com/product-category/Antibodies/">: Antibodies</a>