α7 nAchR-JAK2-STAT3 agonist 1

α7 nAchR-JAK2-STAT3 agonist 1 is a potent α7 nAchR-JAK2-STAT3 agonist, with an IC50 value of 0.32 μM for nitric oxide (NO) . α7 nAchR-JAK2-STAT3 agonist 1 effectively suppresses the expression of iNOS, IL-1β, and IL-6 in murine RAW264.7 macrophages. α7 nAchR-JAK2-STAT3 agonist 1 can inhibit LPS-induced NO release, NF-κB activation and cytokine production. α7 nAchR-JAK2-STAT3 can be used for researching sepsis[1].

Product Specifications

CAS Number

[2108714-20-9]

UNSPSC

12352005

Target

Interleukin Related; JAK; nAChR; NO Synthase; STAT

Type

Reference compound

Related Pathways

Epigenetics; Immunology/Inflammation; JAK/STAT Signaling; Membrane Transporter/Ion Channel; Neuronal Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/α7-nachr-jak2-stat3-agonist-1.html

Purity

99.54

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(O[C@@H](CCCCC1=CC=CC=C1)CCC2=CC=C(OC(C)=O)C(OC(C)=O)=C2)C

Molecular Formula

C25H30O6

Molecular Weight

426.50

References & Citations

[1]Lin Y, et al. Discovery of diarylheptanoids that activate α7 nAchR-JAK2-STAT3 signaling in macrophages with anti-inflammatory activity in vitro and in vivo. Bioorg Med Chem. 2022;66:116811.