Tolimidone
Tolimidone is a potent and selective allosteric activator of Lyn kinase with an EC50 of 63 nM.
Product Specifications
CAS Number
41964-07-2
Product Name Alternative
MLR-1023
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Src
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/Tolimidone.html
Concentration
10mM
Purity
99.98
Solubility
DMSO : 150 mg/mL (ultrasonic)
Smiles
O=C1N=CC(OC2=CC=CC(C)=C2)=CN1
Molecular Formula
C11H10N2O2
Molecular Weight
202.21
Precautions
H302, H315, H319, H335
References & Citations
[1]Saporito MS, et al. MLR-1023 is a potent and selective allosteric activator of Lyn kinase in vitro that improves glucose tolerance in vivo. J Pharmacol Exp Ther. 2012 Jul;342 (1) :15-22.|[2]Ochman AR, et al. The Lyn kinase activator MLR-1023 is a novel insulin receptor potentiator that elicits a rapid-onset and durable improvement in glucose homeostasis in animal models of type 2 diabetes. J Pharmacol Exp Ther. 2012 Jul;342 (1) :23-32.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
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