Tolimidone

Tolimidone is a potent and selective allosteric activator of Lyn kinase with an EC50 of 63 nM.

Product Specifications

CAS Number

[41964-07-2]

Product Name Alternative

MLR-1023

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Src

Type

Reference compound

Related Pathways

Protein Tyrosine Kinase/RTK

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/Tolimidone.html

Concentration

10mM

Purity

99.98

Solubility

DMSO : 150 mg/mL (ultrasonic)

Smiles

O=C1N=CC(OC2=CC=CC(C)=C2)=CN1

Molecular Formula

C11H10N2O2

Molecular Weight

202.21

Precautions

H302, H315, H319, H335

References & Citations

[1]Saporito MS, et al. MLR-1023 is a potent and selective allosteric activator of Lyn kinase in vitro that improves glucose tolerance in vivo. J Pharmacol Exp Ther. 2012 Jul;342 (1) :15-22.|[2]Ochman AR, et al. The Lyn kinase activator MLR-1023 is a novel insulin receptor potentiator that elicits a rapid-onset and durable improvement in glucose homeostasis in animal models of type 2 diabetes. J Pharmacol Exp Ther. 2012 Jul;342 (1) :23-32.