MOZ-IN-3
MOZ-IN-3 (Compound 6j) is a KAT6A (MOZ) acetyltransferase inhibitor (IC50: 30 nM) . MOZ-IN-3 has antitumor activity against four different myeloid leukemia cell lines (HL-60, U937, SKNO-1, K562) . MOZ-IN-3 has favorable metabolic stability and pharmacokinetics[1].
Product Specifications
UNSPSC
12352005
Target
Histone Acetyltransferase
Type
Reference compound
Related Pathways
Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/moz-in-3-1.html
Purity
98.75
Solubility
DMSO : ≥ 200 mg/mL
Smiles
FC1=C(C(CNS(=O)(C2=CC=CC3=C2N=CC=C3)=O)=O)C=CC=C1
Molecular Formula
C17H13FN2O3S
Molecular Weight
344.36
References & Citations
[1]Duan Y, et al. Discovery of N- (2-oxoethyl) sulfanilamide-derived inhibitors of KAT6A (MOZ) against leukemia by an isostere strategy. Eur J Med Chem. 2023 Aug 26;260:115770.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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