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Dendrophenol

Dendrophenol (Moscatilin) is a NF-κB inhibitor that inhibits inflammation. Dendrophenol exerts potent cytotoxic effect against tumor cells and induces cell cycle arrest and apoptosis. Dendrophenol has antitumor activity. In addition, Dendrophenol can inhibit vascular calcification by inhibiting the activation of WNT3/β-catenin[1][2][3][4].

Product Specifications

CAS Number

108853-14-1

Product Name Alternative

Moscatilin

UNSPSC

12352005

Target

Apoptosis; COX; HIF/HIF Prolyl-Hydroxylase; JNK; NF-κB; Wnt; β-catenin

Type

Natural Products

Related Pathways

Apoptosis; Immunology/Inflammation; MAPK/ERK Pathway; Metabolic Enzyme/Protease; NF-κB; Stem Cell/Wnt

Applications

Cancer-programmed cell death

Field of Research

Cancer; Inflammation/Immunology; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/Dendrophenol.html

Purity

99.93

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

COC1=C(C=CC(CCC2=CC(OC)=C(C(OC)=C2)O)=C1)O

Molecular Formula

C17H20O5

Molecular Weight

304.34

References & Citations

[1]Liu YN, et al. Moscatilin repressed lipopolysaccharide-induced HIF-1alpha accumulation and NF-kappaB activation in murine RAW264.7 cells. Shock. 2010 Jan;33 (1) :70-5.|[2]Ho CK, et al. Moscatilin from the orchid Dendrobrium loddigesii is a potential anticancer agent. Cancer Invest. 2003;21 (5) :729-36. |[3]Zhang T, et al. Moscatilin inhibits vascular calcification by activating IL13RA2-dependent inhibition of STAT3 and attenuating the WNT3/β-catenin signalling pathway. J Adv Res. 2024 Mar 2:S2090-1232 (24) 00082-1.|[4]Chen TH, et al. Moscatilin induces apoptosis in human colorectal cancer cells: a crucial role of c-Jun NH2-terminal protein kinase activation caused by tubulin depolymerization and DNA damage. Clin Cancer Res. 2008 Jul 1;14 (13) :4250-8.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C (Powder, protect from light)

Scientific Category

Natural Products

Clinical Information

No Development Reported

Isoform

COX-2; HIF-1α; NF-κB; Wnt3

Available Sizes

Frequently Asked Questions

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