ODN 24888 (sodium)
ODN 24888 sodium is an guanine-modified inhibitory oligonucleotides (INH-ODN), shows potent inhibition on TLR7/TLR9-mediated signaling. ODN 24888 sodium impairs IFN-α level and NF-κB activation, inhibits IL-6 release. ODN 24888 sodium involves in immune and inflammatory responses, can be used as a vaccine adjuvant[1][2].
Product Specifications
UNSPSC
12352208
Target
Toll-like Receptor (TLR)
Type
Oligonucleotides
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/odn-24888-sodium.html
Purity
98.70
Solubility
10 mM in H2O
Smiles
[ODN24888(sodium)]
Molecular Weight
4904 (free acid)
References & Citations
[1]Saul Meike, et al. Reduction of bone resorption, especially in chronic joint diseases: Germany, DE102019122014 A1. 2021-02-18.|[2]Römmler F, et al. Guanine-modified inhibitory oligonucleotides efficiently impair TLR7- and TLR9-mediated im mune responses of human immune cells. PLoS One. 2015 Feb 19;10 (2) :e0116703.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Oligonucleotides
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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