VDX-111

VDX-111 is an analog of vitamin D. VDX-111 exhibits cytotoxicity in ovarian cancer cells through upregulation of RIPK1/RIPK3 pathway and induction of necroptosis. VDX-111 promotes expressions of cytokines and exhibits antitumor activity in mouse model[1].

Product Specifications

CAS Number

[158983-23-4]

UNSPSC

12352211

Target

Necroptosis; RIP kinase

Type

Reference compound

Related Pathways

Apoptosis

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/vdx-111.html

Solubility

10 mM in DMSO

Smiles

C[C@]([C@@]1([H])[C@H](C)CCCC(C)(O)C)(CCC/2)[C@](CC1)([H])C2=C\C=C(C([C@H]3O)=C)\C[C@H](C3)OC(CBr)=O

Molecular Formula

C29H45BrO4

Molecular Weight

537.57

References & Citations

[1]Persenaire C, et al., VDX-111, a novel small molecule, induces necroptosis to inhibit ovarian cancer progression. Mol Carcinog. 2024 Apr 1.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Curated Selection

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