VDX-111
VDX-111 is an analog of vitamin D. VDX-111 exhibits cytotoxicity in ovarian cancer cells through upregulation of RIPK1/RIPK3 pathway and induction of necroptosis. VDX-111 promotes expressions of cytokines and exhibits antitumor activity in mouse model[1].
Product Specifications
CAS Number
[158983-23-4]
UNSPSC
12352211
Target
Necroptosis; RIP kinase
Type
Reference compound
Related Pathways
Apoptosis
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/vdx-111.html
Solubility
10 mM in DMSO
Smiles
C[C@]([C@@]1([H])[C@H](C)CCCC(C)(O)C)(CCC/2)[C@](CC1)([H])C2=C\C=C(C([C@H]3O)=C)\C[C@H](C3)OC(CBr)=O
Molecular Formula
C29H45BrO4
Molecular Weight
537.57
References & Citations
[1]Persenaire C, et al., VDX-111, a novel small molecule, induces necroptosis to inhibit ovarian cancer progression. Mol Carcinog. 2024 Apr 1.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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