AIF Blocking Peptide

<strong>AIF Blocking Peptide</strong>_x000D_ <strong>Catalog number:</strong> B2017234_x000D_ <strong>Lot number:</strong> Batch Dependent_x000D_ <strong>Expiration Date:</strong> Batch dependent_x000D_ <strong>Amount:</strong> 200 µg_x000D_ <strong>Molecular Weight or Concentration:</strong> N/A_x000D_ <strong>Supplied as:</strong> Powder_x000D_ <strong>Applications:</strong> a molecular tool for various biochemical applications_x000D_ <strong>Storage:</strong> -20°C_x000D_ <strong>Keywords:</strong> Apoptosis-Inducing Factor, Programmed Cell Death Protein 8_x000D_ <strong>Grade:</strong> Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity &gt;18 MΩ-cm) and are filtered through 0.22 um._x000D_ _x000D_ <strong>References:</strong>_x000D_ 1: Wang Y, An R, Umanah GK, Park H, Nambiar K, Eacker SM, Kim B, Bao L, Harraz MM, Chang C, Chen R, Wang JE, Kam TI, Jeong JS, Xie Z, Neifert S, Qian J, Andrabi SA, Blackshaw S, Zhu H, Song H, Ming GL, Dawson VL, Dawson TM. A nuclease that mediates cell death induced by DNA damage and poly(ADP-ribose) polymerase-1 Science. 2016 Oct 7;354(6308):aad6872._x000D_ 2: Chelko SP, Keceli G, Carpi A, Doti N, Agrimi J, Asimaki A, Beti CB, Miyamoto M, Amat-Codina N, Bedja D, Wei AC, Murray B, Tichnell C, Kwon C, Calkins H, James CA, O'Rourke B, Halushka MK, Melloni E, Saffitz JE, Judge DP, Ruvo M, Kitsis RN, Andersen P, Di Lisa F, Paolocci N. Exercise triggers CAPN1-mediated AIF truncation, inducing myocyte cell death in arrhythmogenic cardiomyopathy Sci Transl Med. 2021 Feb 17;13(581):eabf0891._x000D_ 3: Modjtahedi N, Giordanetto F, Madeo F, Kroemer G. Apoptosis-inducing factor: vital and lethal Trends Cell Biol. 2006 May;16(5):264-72._x000D_ 4: Dawson VL, Dawson TM. Deadly conversations: nuclear-mitochondrial cross-talk J Bioenerg Biomembr. 2004 Aug;36(4):287-94._x000D_ 5: Rodriguez J, Xie C, Li T, Sun Y, Wang Y, Xu Y, Li K, Zhang S, Zhou K, Wang Y, Mallard C, Hagberg H, Doti N, Wang X, Zhu C. Inhibiting the interaction between apoptosis-inducing factor and cyclophilin A prevents brain injury in neonatal mice after hypoxia-ischemia Neuropharmacology. 2020 Jul;171:108088._x000D_ 6: Zhang Y, Zhang C, Li J, Jiang M, Guo S, Yang G, Zhang L, Wang F, Yi S, Wang J, Fu Y, Zhang Y. Inhibition of AKT induces p53/SIRT6/PARP1-dependent parthanatos to suppress tumor growth Cell Commun Signal. 2022 Jun 17;20(1):93._x000D_ 7: Monti A, Sturlese M, Caporale A, Roger JA, Mascanzoni F, Ruvo M, Doti N. Design, synthesis, structural analysis and biochemical studies of stapled AIF(370-394) analogues as ligand of CypA Biochim Biophys Acta Gen Subj. 2020 Dec;1864(12):129717._x000D_ 8: Greenwald SH, Pierce EA. Parthanatos as a Cell Death Pathway Underlying Retinal Disease Adv Exp Med Biol. 2019;1185:323-327._x000D_ 9: Song Y, Fan Z, Bai X, Liu W, Han Y, Xu L, Wang M, Li J, Zheng Q, Zhang D, Wang H. PARP-1-modulated AIF translocation is involved in streptomycin-induced cochlear hair cell death Acta Otolaryngol. 2016 Jun;136(6):545-50._x000D_ <a href="https://pubmed.ncbi.nlm.nih.gov/18848916">10: Galluzzi L, Morselli E, Kepp O, Kroemer G. Targeting post-mitochondrial effectors of apoptosis for neuroprotection Biochim Biophys Acta. 2009 May;1787(5):402-13. </a>_x000D_ _x000D_ <strong>Products Related to AIF Blocking Peptide can be found at</strong> <a href="https://moleculardepot.com/product-category/Proteins/"> Proteins</a>