2-Methylthio-AMP (sodium)
2-Methylthio-AMP sodium is a selective and direct P2Y12 antagonist. 2-Methylthio-AMP sodium is an inhibitor of ADP-dependent platelet aggregation[1][2][3].
Product Specifications
CAS Number
81921-45-1
UNSPSC
12352005
Target
P2Y Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/2-methylthio-amp-sodium.html
Smiles
O[C@H]1[C@@H](O)[C@H](N2C3=C(N=C2)C(N)=NC(SC)=N3)O[C@@H]1COP(O[Na])(O[Na])=O
Molecular Formula
C11H14N5Na2O7PS
Molecular Weight
437.28
References & Citations
[1]John H Cleator, et al. Racial differences in resistance to P2Y12 receptor antagonists in type 2 diabetic subjects. J Pharmacol Exp Ther. 2014 Oct;351 (1) :33-43.|[2]Bernhard H Rauch, et al. Regulation of functionally active P2Y12 ADP receptors by thrombin in human smooth muscle cells and the presence of P2Y12 in carotid artery lesions. Arterioscler Thromb Vasc Biol. 2010 Dec;30 (12) :2434-42.|[3]A Malinin, et al. Validation of a VerifyNow-P2Y12 cartridge for monitoring platelet inhibition with clopidogrel. Methods Find Exp Clin Pharmacol. 2006 Jun;28 (5) :315-22.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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