Recombinant Aldose reductase 1B1 Antibody / AKR1B1

AKR1B1, also designated as aldose reductase, is a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This protein catalyzes the reduction of a number of aldehydes, including the aldehyde form of glucose, and is thereby implicated in the development of diabetic complications by catalyzing the reduction of glucose to sorbitol. It has also been shown to have decreased expression in adrenocortical cancer, and possibly play a role in adrenal tumorigenesis. It has been suggested that AKR1B1 could be investigated as a marker of malignancy for adrenal tumor diagnosis.

Product Specifications

CAS Number

9000-83-3

Specifications

Immunofluorescence: 1-2 µg/mL, Western blot: 2-4 µg/mL, Immunohistochemistry (FFPE) : 1-2 µg/mL

UniProt

P15121

Host

Mouse

Reactivity

Human

Immunogen

Recombinant human full-length protein was used as the immunogen for the recombinant Aldose reductase 1B1 antibody.

Clonality

Recombinant Monoclonal

Isotype

IgG1 k

Clone

RAKR1B1/7296

Type

Recombinant

Applications

IF, WB, IHC-P

Purity

Protein A/G affinity

Format

Purified

Buffer

0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide

Reconstitution

Aliquot the recombinant Aldose reductase 1B1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Limitations

This recombinant Aldose reductase 1B1 antibody is available for research use only.

Storage Conditions

Aliquot the recombinant Aldose reductase 1B1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Formulation

0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05% sodium azide

Applications Notes

Optimal dilution of the recombinant Aldose reductase 1B1 antibody should be determined by the researcher.

Location

Cytoplasm

Image Legend

Western blot testing of human 293T cell lysate with recombinant Aldose reductase 1B1 antibody (clone rAKR1B1/7296) . Predicted molecular weight ~36 kDa.