B-cell lymphoma/leukemia 11A Antibody / BCL11A
Bcl-11a (CtIP-1, EVI9, B cell chronic lymphocytic leukemia (CLL) /lymphoma 11A) and Bcl-11b (CtIP-2, RIT1, B cell CLL/lymphoma 11B) genes play crucial roles in lymphopoiesis and influence the progression of hematopoietic malignancies. Disruption of the Bcl-11b locus is linked to T cell acute lymphoblastic leukemia, and the loss of heterozygosity in mice results in T cell lymphoma. Bcl-11 proteins are related C2H2 zinc-finger transcription factors that act as transcriptional repressors. Bcl-11b can interact with the metastasis-associated proteins MTA1 and MTA2 through the amino-terminal region. Bcl-11a is essential for postnatal development and normal lymphopoiesis. The Bcl-11a mouse gene is a common site of retroviral integration in myeloid leukemia, and may function as a leukemia disease gene, in part, through its interaction with Bcl-6.
Product Specifications
CAS Number
9007-83-4
Specifications
ELISA (order BSA-free format for coating), Flow cytometry: 1-2ug/million cells, Immunofluorescence: 1-2 µg/mL
UniProt
Q9H165
Host
Mouse
Reactivity
Human
Immunogen
Recombinant full-length human protein was used as the immunogen for the B-cell lymphoma/leukemia 11A antibody.
Clonality
Monoclonal
Isotype
IgG1
Clone
PCRP-BCL11A-1H3
Applications
ELISA, FACS, IF
Purity
Protein A/G affinity
Format
Purified
Buffer
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Reconstitution
Aliquot the B-cell lymphoma/leukemia 11A antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This B-cell lymphoma/leukemia 11A antibody is available for research use only.
Storage Conditions
Aliquot the B-cell lymphoma/leukemia 11A antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05% sodium azide
Applications Notes
Optimal dilution of the B-cell lymphoma/leukemia 11A antibody should be determined by the researcher.
Location
Cytoplasm, Nucleus
Image Legend
FACS staining of PFA-fixed human HeLa cells with B-cell lymphoma/leukemia 11A antibody (blue, clone PCRP-BCL11A-1H3) and isotype control (red) .
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