MASPIN Antibody / SERPINB5
Maspin is structurally a serine protease inhibitor (serpin) that was initially isolated from normal human mammary epithelial cells. Serpins are a family of proteins that inhibit Chymotrypsin-like serine proteinases. Serpins control activated proteinases and several are involved in the regulation of cell death. Maspin is found in the extracellular matrix and at the plasma membrane. Maspin has been shown to act at the cell surface to block cell motility and inhibit invasion of breast and prostate cancer cells. Maspin is present in normal mammary epithelial cells but is absent in many tumor cell lines, yet no major structural alterations of the Maspin gene have been identified in tumor cells. Similarly, Maspin is expressed in normal prostate cells and downregulated or absent in prostate tumor cells.
Product Specifications
CAS Number
9007-83-4
Specifications
Western blot: 1-2 µg/mL, Immunohistochemistry (FFPE) : 1-2 µg/mL
UniProt
P36952
Host
Mouse
Reactivity
Human
Immunogen
A portion of amino acids1-200 was used as the immunogen for the MASPIN antibody.
Clonality
Monoclonal
Isotype
IgG1 k
Clone
SERPINB5/4977
Applications
WB, IHC-P
Purity
Protein A/G affinity
Format
Purified
Buffer
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Reconstitution
Aliquot the MASPIN antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This MASPIN antibody is available for research use only.
Storage Conditions
Aliquot the MASPIN antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05% sodium azide
Applications Notes
Optimal dilution of the MASPIN antibody should be determined by the researcher.
Location
Secreted, Extracellular space
Image Legend
Western blot testing of human PC3 cell lysate using MASPIN antibody (clone SERPINB5/4977) . Predicted molecular weight: 42~45 kDa.
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