MICA Antibody
MICA and MICB are stress-induced antigens that are related to major histocompatibility complex (MHC) class I molecules. MICA and MICB are frequently expressed in epithelial tumors. These highly glycosylated cell surface proteins are stably expressed without conventional class I peptide ligands or association with -2-microglobulin. The expression is induced on proliferating or heat shock-stressed epithelial cells. MICA and MICB are broadly recognized by intestinal epithelial γδ T cells expressing variable TCRs, suggesting that these antigens may play a central role in the signaling of cellular distress to evoke immune responses in the intestinal epithelium.
Product Specifications
UniProt
Q29983
Host
Mouse
Immunogen
A portion of amino acids 1-200 was used as the immunogen for the MICA antibody.
Clonality
Monoclonal
Isotype
IgG2b κ
Applications
WB, IHC-P
Format
Purified
Buffer
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Reconstitution
Aliquot the MICA antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This MICA antibody is available for research use only.
CAS Number
9007-83-4
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