ZNF81 Antibody

Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. The majority of zinc-finger proteins contain a krueppel-type DNAbinding domain and a KRAB domain, which is thought to interact with KAP1, thereby recruiting histone modifying proteins. ZNF81, also known as HFZ20 or MRX45, is a transcriptional regulator belonging to the krueppel C2H2-type zincfinger protein family. It localizes to the nucleus and contains 12 C2H2-type zinc fingers and one KRAB domain. Mutations in the gene encoding ZNF81 are implicated in nonsyndromic X-linked mental retardation (XLMR) .

Product Specifications

CAS Number

9007-83-4

Specifications

ELISA (order BSA-free format for coating), Western blot: 1-2 µg/mL, Flow cytometry: 1-2ug/million cells, Immunofluorescence: 1-2 µg/mL

UniProt

P51508

Host

Mouse

Reactivity

Human

Immunogen

Recombinant full-length human ZNF81 protein was used as the immunogen for the ZNF81 antibody.

Clonality

Monoclonal

Isotype

IgG2a

Clone

PCRP-ZNF81-2G2

Applications

ELISA, WB, FACS, IF

Purity

Protein A/G affinity

Format

Purified

Buffer

0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide

Reconstitution

Aliquot the ZNF81 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Limitations

This ZNF81 antibody is available for research use only.

Storage Conditions

Aliquot the ZNF81 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Formulation

0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05% sodium azide

Applications Notes

Optimal dilution of the ZNF81 antibody should be determined by the researcher.

Location

Nucleus, Cytoplasm

Image Legend

Immunofluorescent staining of PFA-fixed human HeLa cells using ZNF81 antibody (green, clone PCRP-ZNF81-2G2) and phalloidin (red) .

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