Glutamine Synthetase Antibody / GLUL
Glutamine synthetase (GlSyn) forms a homo-octamer that serves as a catalyst for the amination of glutamic acid to form glutamine. This enzyme is a marker for astrocytes, which serve as the primary site of conversion of glutamic acid to glutamine in the brain. Induction of glutamine synthetase is seen upon astrocyte cell contact with neurons. Elevated expression of glutamine synthetase in glial cells has been shown to protect neurons from degeneration due to excess glutamate. Glutamine synthetase is also present in the liver and is involved in nitrogen homeostasis. Overexpression of glutamine synthetase has been shown in primary liver cancers, indicating a potential role for glutamine synthetase in hepatocyte transformation.
Product Specifications
CAS Number
9007-83-4
Specifications
Western blot: 1-2 µg/mL, Immunohistochemistry (FFPE) : 1-2 µg/mL
UniProt
P15104
Host
Mouse
Reactivity
Human
Immunogen
A portion of amino acids 50-250 was used as the immunogen for the GLUL antibody.
Clonality
Monoclonal
Isotype
IgG2b κ
Clone
GLUL/6599
Applications
WB, IHC-P
Purity
Protein A/G affinity
Format
Purified
Buffer
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Reconstitution
Aliquot the GLUL antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This GLUL antibody is available for research use only.
Storage Conditions
Aliquot the GLUL antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05% sodium azide
Applications Notes
Optimal dilution of the GLUL antibody should be determined by the researcher.
Location
Cytoplasm
Image Legend
Western blot testing of human liver tissue using GLUL antibody (clone GLUL/6599) . Predicted molecular weight ~42 kDa.
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