TDRKH Antibody
Participates in the primary piRNA biogenesis pathway and is required during spermatogenesis to repress transposable elements and prevent their mobilization, which is essential for the germline integrity. The piRNA metabolic process mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Required for the final steps of primary piRNA biogenesis by participating in the processing of 31-37 nt intermediates into mature piRNAs. May act in pi-bodies and piP-bodies by transferring piRNA precursors or intermediates to or between these granules.
Product Specifications
CAS Number
9007-83-4
Specifications
Flow cytometry: 1-2ug/million cells, Immunofluorescence: 1-2 µg/mL, Western blot: 1-2 µg/mL, Immunohistochemistry (FFPE) : 1-2 µg/mL
UniProt
Q9Y2W6
Host
Mouse
Reactivity
Human
Immunogen
Recombinant full-length human TDRKH protein was used as the immunogen for the TDRKH antibody.
Clonality
Monoclonal
Isotype
IgG2b
Clone
PCRP-TDRKH-1H2
Applications
FACS, IF, WB, IHC-P
Purity
Protein A/G affinity
Format
Purified
Buffer
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Reconstitution
Aliquot the TDRKH antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This TDRKH antibody is available for research use only.
Storage Conditions
Aliquot the TDRKH antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05% sodium azide
Applications Notes
Optimal dilution of the TDRKH antibody should be determined by the researcher.
Location
Cytoplasm
Image Legend
Immunofluorescent staining of PFA-fixed human HeLa cells using TDRKH antibody (green, clone PCRP-TDRKH-1H2) and phalloidin (red) .
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