FGF-23 Antibody / Fibroblast Growth Factor 23

Fibroblast growth factor-1 (FGF-1), also designated acidic FGF, and fibroblast growth factor-2 (FGF-2), also designated basic FGF, are members of a family of growth factors that stimulate proliferation of cells of mesenchymal, epithelial and neuroectodermal origin. Additional members of the FGF family include the oncogenes FGF-3 (Int2) and FGF-4 (hst/Kaposi), FGF-5, FGF-6, FGF-7 (KGF), FGF-8 (AIGF), FGF-9 (GAF) and FGF-10 through FGF-23. Members of the FGF family share 30-55% amino acid sequence identity and similar gene structure, and are capable of transforming cultured cells when overexpressed in transfected cells. Cellular receptors for FGFs are members of a second multigene family, including four tyrosine kinases designated Flg (FGFR-1), Bek (FGFR-L), TKF and FGFR-3.

Product Specifications

CAS Number

9007-83-4

Specifications

Immunohistochemistry (FFPE) : 1-2 µg/mL

UniProt

Q9GZV9

Host

Mouse

Reactivity

Human

Immunogen

A portion of amino acids 25-251 was used as the immunogen for the FGF-23 antibody.

Clonality

Monoclonal

Isotype

IgG2b κ

Clone

FGF23/4171

Applications

IHC-P

Purity

Protein A/G affinity

Format

Purified

Buffer

0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide

Reconstitution

Aliquot the FGF-23 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Limitations

This FGF-23 antibody is available for research use only.

Storage Conditions

Aliquot the FGF-23 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Formulation

0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05% sodium azide

Applications Notes

Optimal dilution of the FGF-23 antibody should be determined by the researcher.

Location

Secreted (extracellular)

Image Legend

IHC staining of FFPE human kidney tissue with FGF-23 antibody (clone FGF23/4171) 2ug/ml in PBS for 30min RT. HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.