IL1 beta Antibody / IL1B
The IL1 beta cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2.
Product Specifications
UniProt
P01584
Host
Mouse
Immunogen
A recombinant protein fragment was used as the immunogen for the IL1B antibody.
Clonality
Monoclonal
Isotype
IgG2b κ
Applications
ELISA, IHC-P
Format
Purified
Buffer
1 mg/ml in 1X PBS; BSA free, sodium azide free
Reconstitution
Aliquot the IL1B antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This IL1B antibody is available for research use only.
CAS Number
9007-83-4
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