IGFBP3 Antibody

The Insulin-like growth factor-binding proteins, or IGFBPs, are a family of homologous proteins that have co-evolved with the IGFs. They serve not only as shuttle molecules for the soluble IGFs, but also confer a level of regulation to the IGF signaling system. IGFBP3 is the most abundant IGFBP and is complexed with roughly 80% of the serum IGFs.

Product Specifications

CAS Number

9007-83-4

Specifications

Immunohistochemistry (FFPE) : 1-2 µg/mL

UniProt

P17936

Host

Mouse

Reactivity

Human

Immunogen

Recombinant human full-length IGFBP3 protein was used as the immunogen for the IGFBP3 antibody.

Clonality

Monoclonal

Isotype

IgG2b κ

Clone

IGFBP3/3517

Applications

IHC-P

Purity

Protein A/G affinity

Format

Purified

Buffer

0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide

Reconstitution

Aliquot the IGFBP3 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Limitations

This IGFBP3 antibody is available for research use only.

Storage Conditions

Aliquot the IGFBP3 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Formulation

0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05% sodium azide

Applications Notes

Optimal dilution of the IGFBP3 antibody should be determined by the researcher.

Location

Cytoplasm, Nucleus

Image Legend

Analysis of HuProt (TM) microarray containing more than 19,000 full-length human proteins using IGFBP3 antibody (clone IGFBP3/3517) . These results demonstrate the foremost specificity of the IGFBP3/3517 mAb. Z- and S- score: The Z-score represents the strength of a signal that an antibody (in combination with a fluorescently-tagged anti-IgG secondary Ab) produces when binding to a particular protein on the HuProt (TM) array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If the targets on the HuProt (TM) are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-scores. The S-score therefore represents the relative target specificity of an Ab to its intended target.