FOXL1 Antibody
FOXL1 is a 337 amino acid protein encoded by the mouse gene FOXL1. FOXL1 belongs to the forkhead family and contains one forkhead DNA-binding domain. The HNF3/forkhead family includes a large number of transcription factors that share a structurally related DNA binding domain. forkhead factors are known to play important roles both during development and in adults. FOXL1 is a winged helix transcriptional regulator expressed in the mesenchymal layer of developing and mature gastrointestinal tract. FOXL1-deficient mice exhibit various defects not only in the epithelial layer of the gastrointestinal tract but also in gut-associated lymphoid tissues. In the small intestine of FOXL1-deficient mice, the formation of Peyers patches is affected, particularly in the caudal region. FOXL1 is a mesenchymal modifier of the Adenomatous Polyposis Coli (APC) gene products and plays a key role in gastrointestinal tumorigenesis.
Product Specifications
CAS Number
9007-83-4
Specifications
Flow cytometry: 1-2ug/million cells, Immunofluorescence: 1-2 µg/mL, Western blot: 1-2 µg/mL, Immunohistochemistry (FFPE) : 1-2 µg/mL
UniProt
Q12951
Host
Mouse
Reactivity
Human
Immunogen
A portion of amino acids 104-258 was used as the immunogen for the FOXL1 antibody.
Clonality
Monoclonal
Isotype
IgG1
Clone
PCRP-FOXL1-1F8
Applications
FACS, IF, WB, IHC-P
Purity
Protein A/G affinity
Format
Purified
Buffer
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Reconstitution
Aliquot the FOXL1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This FOXL1 antibody is available for research use only.
Storage Conditions
Aliquot the FOXL1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Product Datasheet
https://www.nsjbio.com/tds-pdf/foxl1-antibody-pcrp-foxl1-1f8-v9554
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05% sodium azide
Applications Notes
Optimal dilution of the FOXL1 antibody should be determined by the researcher.
Location
Nucleus
Image Legend
Immunofluorescent staining of PFA-fixed human HeLa cells using FOXL1 antibody (green, clone PCRP-FOXL1-1F8) and phalloidin (red) .
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