Recombinant GZMB Antibody / Granzyme B
Granzyme B is a member of the granule serine protease family stored specifically in NK cells or cytotoxic T cells. Cytolytic T lymphocytes (CTL) and natural killer (NK) cells share the ability to recognize, bind, and lyse specific target cells. They are thought to protect their host by lysing cells bearing on their surface antigens, usually peptides or proteins resulting from infection by intracellular pathogens. Granzyme B is crucial for the rapid induction of target cell apoptosis by CTLs in the cell-mediated immune response. Granzyme B is useful as a marker in the identification of NK/T-cell lymphomas. High percentages of cytotoxic T-cells have been shown to be an unfavorable prognostic indicator in Hodgkin s Disease.
Product Specifications
CAS Number
9000-83-3
Specifications
Western blot: 1-2 µg/mL, Immunohistochemistry (FFPE) : 1-2 µg/mL
UniProt
P10144
Host
Mouse
Reactivity
Human
Immunogen
A portion of amino acids 73-187 was used as the immunogen for the recombinant GZMB antibody.
Clonality
Recombinant Monoclonal
Isotype
IgG2a κ
Clone
RGZMB/4538
Type
Recombinant
Applications
WB, IHC-P
Purity
Protein A/G affinity
Format
Purified
Buffer
1 mg/ml in 1X PBS; BSA free, sodium azide free
Reconstitution
Aliquot the recombinant GZMB antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This recombinant GZMB antibody is available for research use only.
Storage Conditions
Aliquot the recombinant GZMB antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
1 mg/mL in 1X PBS; BSA free, sodium azide free
Applications Notes
Optimal dilution of the recombinant GZMB antibody should be determined by the researcher.
Location
Cytoplasm
Image Legend
Western blot testing of human spleen tissue lysate using recombinant GZMB antibody (clone rGZMB/4538) . Predicted molecular weight: 29-37 kDa.
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