Fibronectin 1 Antibody / FN1
Fibronectins are disulfide-linked, dimeric glycoproteins of ~440kDa. They possess at least four binding sites for collagen, glycosaminoglycans, transglutaminase, and a cell surface receptor. Epitope of this MAb is located in the 2nd-3rd type-III repeats of fibronectin. Fibronectins are extracellular matrix glycoproteins that are essential for embryonic development. Fibronectins are also involved in cell adhesion, tissue organization, and wound healing. Fibronectins are present in basement membranes, interstitial connective tissue matrix, and blood. Cellular fibronectin is widely distributed in the stroma of many malignant tumors. This MAb reacts with human cellular fibronectin, but not plasma fibronectin.
Product Specifications
CAS Number
9007-83-4
Specifications
ELISA (order BSA-free format for coating), Immunohistochemistry (FFPE) : 1-2 µg/mL
UniProt
P02751
Host
Mouse
Reactivity
Human
Immunogen
A portion of amino acids 467-595 was used as the immunogen for the Fibronectin 1 antibody.
Clonality
Monoclonal
Isotype
IgG2b κ
Clone
FN1/3569
Applications
ELISA, IHC-P
Purity
Protein A/G affinity
Format
Purified
Buffer
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Reconstitution
Aliquot the Fibronectin 1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This Fibronectin 1 antibody is available for research use only.
Storage Conditions
Aliquot the Fibronectin 1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05% sodium azide
Applications Notes
Optimal dilution of the Fibronectin 1 antibody should be determined by the researcher.
Location
Connective tissue matrix
Image Legend
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