PZM21
PZM21 is a potent and selective μ opioid receptor agonist with an EC50 of 1.8 nM[1][2][3].
Product Specifications
CAS Number
1997387-43-5
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Opioid Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/PZM21.html
Purity
99.87
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(N[C@@H](C)CC1=CSC=C1)NC[C@@H](N(C)C)CC2=CC=C(O)C=C2
Molecular Formula
C19H27N3O2S
Molecular Weight
361.50
Precautions
H302, H315, H319, H335
References & Citations
[1]Manglik A, et al. Structure-based discovery of opioid analgesics with reduced side effects. Nature. 2016 Sep 8;537 (7619) :185-190.|[2]Kostic M, et al. Biasing Opioid Receptors and Cholesterol as a Player in Developmental Biology.|[3]Araldi D, et al. Mu-opioid Receptor (MOR) Biased Agonists Induce Biphasic Dose-dependent Hyperalgesia and Analgesia, and Hyperalgesic Priming in the Rat. Neuroscience. 2018 Oct 17;394:60-71.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
μ Opioid Receptor/MOR
Available Sizes
Frequently Asked Questions
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