PZM21

PZM21 is a potent and selective μ opioid receptor agonist with an EC50 of 1.8 nM[1][2][3].

Product Specifications

CAS Number

[1997387-43-5]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Opioid Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/PZM21.html

Purity

99.87

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(N[C@@H](C)CC1=CSC=C1)NC[C@@H](N(C)C)CC2=CC=C(O)C=C2

Molecular Formula

C19H27N3O2S

Molecular Weight

361.50

Precautions

H302, H315, H319, H335

References & Citations

[1]Manglik A, et al. Structure-based discovery of opioid analgesics with reduced side effects. Nature. 2016 Sep 8;537 (7619) :185-190.|[2]Kostic M, et al. Biasing Opioid Receptors and Cholesterol as a Player in Developmental Biology.|[3]Araldi D, et al. Mu-opioid Receptor (MOR) Biased Agonists Induce Biphasic Dose-dependent Hyperalgesia and Analgesia, and Hyperalgesic Priming in the Rat. Neuroscience. 2018 Oct 17;394:60-71.