Fibroblast Growth Factor 23 Antibody / FGF-23

Fibroblast growth factor-1 (FGF-1), also designated acidic FGF, and fibroblast growth factor-2 (FGF-2), also designated basic FGF, are members of a family of growth factors that stimulate proliferation of cells of mesenchymal, epithelial and neuroectodermal origin. Additional members of the FGF family include the oncogenes FGF-3 (Int2) and FGF-4 (hst/Kaposi), FGF-5, FGF-6, FGF-7 (KGF), FGF-8 (AIGF), FGF-9 (GAF) and FGF-10 through FGF-23. Members of the FGF family share 30-55% amino acid sequence identity and similar gene structure, and are capable of transforming cultured cells when overexpressed in transfected cells. Cellular receptors for FGFs are members of a second multigene family, including four tyrosine kinases designated Flg (FGFR-1), Bek (FGFR-L), TKF and FGFR-3.

Product Specifications

CAS Number

9007-83-4

Specifications

Immunohistochemistry (FFPE) : 1-2 µg/mL

UniProt

Q9GZV9

Host

Mouse

Reactivity

Human

Immunogen

A recombinant fragment (within amino acids 100-251) of human FGF23 protein was used as the immunogen for the Fibroblast Growth Factor 23 antibody.

Clonality

Monoclonal

Isotype

IgG2b κ

Clone

FGF23/9059

Applications

IHC-P

Purity

Protein A/G affinity

Format

Purified

Buffer

0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide

Reconstitution

Aliquot the Fibroblast Growth Factor 23 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Limitations

This Fibroblast Growth Factor 23 antibody is available for research use only.

Storage Conditions

Aliquot the Fibroblast Growth Factor 23 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Formulation

0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05% sodium azide

Applications Notes

Optimal dilution of the Fibroblast Growth Factor 23 antibody should be determined by the researcher.

Location

Secreted (extracellular)

Image Legend

IHC staining of FFPE human kidney tissue with Fibroblast Growth Factor 23 antibody (clone FGF23/9059) . Inset: PBS used in place of primary Ab (secondary Ab negative control) . HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.