ZNF804A Antibody / Zinc finger protein 804A

Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. The majority of zinc-finger proteins contain a Krppel-type DNA binding domain and a KRAB domain, which is thought to interact with KAP1, thereby recruiting histone modifying proteins. ZNF804A (zinc-finger protein 804A) is a 1,209 amino acid protein that contains one C2H2-type zinc finger. ZNF804A interacts with Ataxin-1, a protein that is involved in RNA metabolism. The gene encoding ZNF804A maps to human chromosome 2, which consists of 237 million bases and encodes over 1,400 genes, making up approximately 8% of the human genome. A number of genetic diseases are linked to genes on chromosome 2.

Product Specifications

CAS Number

9007-83-4

Specifications

Immunohistochemistry (FFPE) : 1-2 µg/mL

UniProt

Q7Z570

Host

Mouse

Reactivity

Human

Immunogen

Recombinant full-length human ZNF804A protein was used as the immunogen for the ZNF804A antibody.

Clonality

Monoclonal

Isotype

IgG2a κ

Clone

ZNF804A/8945

Applications

IHC-P

Purity

Protein A/G affinity

Format

Purified

Buffer

0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide

Reconstitution

Aliquot the ZNF804A antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Limitations

This ZNF804A antibody is available for research use only.

Storage Conditions

Aliquot the ZNF804A antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Formulation

0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05% sodium azide

Applications Notes

Optimal dilution of the ZNF804A antibody should be determined by the researcher.

Location

Nucleus

Image Legend

IHC staining of FFPE human skeletal muscle tissue with ZNF408A antibody (clone ZNF804A/8945) . Inset: PBS used in place of primary Ab (secondary Ab negative control) . HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.