Opa-interacting protein 4 Antibody / OIP-4 / PRAME
Functions as a transcriptional repressor, inhibiting the signaling of retinoic acid through the retinoic acid receptors RARA, RARB and RARG. Prevents retinoic acid-induced cell proliferation arrest, differentiation and apoptosis. This gene encodes an antigen that is preferentially expressed in human melanomas and that is recognized by cytolytic T lymphocytes. It is not expressed in normal tissues, except testis. The encoded protein acts as a repressor of retinoic acid receptor, and likely confers a growth advantage to cancer cells via this function. Alternative splicing results in multiple transcript variants.
Product Specifications
CAS Number
9007-83-4
Specifications
Immunohistochemistry (FFPE) : 1-2 µg/mL
UniProt
P78395
Host
Mouse
Reactivity
Human
Immunogen
A recombinant fragment (within amino acids 100-250) of human PRAME protein was used as the immunogen for the Opa-interacting protein 4 antibody.
Clonality
Monoclonal
Isotype
IgG2b κ
Clone
PRAME/9189
Applications
IHC-P
Purity
Protein A/G affinity
Format
Purified
Buffer
1 mg/ml in 1X PBS; BSA free, sodium azide free
Reconstitution
Aliquot the PRAME antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This Opa-interacting protein 4 antibody is available for research use only.
Storage Conditions
Aliquot the PRAME antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
1 mg/mL in 1X PBS; BSA free, sodium azide free
Applications Notes
Optimal dilution of the PRAME antibody should be determined by the researcher.
Location
Nucleus, Cytoplasm, Cell membrane
Image Legend
Frequently Asked Questions
Explore Other Products
Browse additional items from our catalog
1,2,3,4-Tetrahydro-2-oxo-3-quinolineacetic Acid Methyl Ester
1,2,3,4-Tetrahydro-2-oxo-3-quinolineacetic Acid Methyl Ester
Lentiviral human BHMT shRNA (UAS) - Lentiviral human BHMT shRNA (UAS, iRFP) (100)
Rabbit anti-Escherichia coli (strain 8739/DSM 1576/Crooks) RUVA Polyclonal Antibody
