COL4A5 Antibody / Collagen IV
Type IV collagen is the major structural component of the glomerular basement membrane (GBM), forming a hexagonal network together with lamins, proteoglycans, and nestin. Deletions of the N-terminal regions of COL4A5 and COL4A6 were found in Xq22.3 chromosome deletion syndrome and were located in an end-to-end manner. This results in a phenotype characteristic of diffuse leiomyomatosis and Alport syndrome (DL-ATS) .
Product Specifications
CAS Number
9000-83-3
Specifications
Immunohistochemistry (FFPE) : 1-2 µg/mL
UniProt
P29400
Host
Rabbit
Reactivity
Human
Immunogen
A recombinant fragment (within amino acids 1400-1685) of human COL4A protein was used as the immunogen for the COL4A5 antibody.
Clonality
Recombinant Monoclonal
Isotype
IgG κ
Clone
COL4A5/9396R
Type
Recombinant
Applications
IHC-P
Purity
Protein A/G affinity
Format
Purified
Buffer
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Reconstitution
Aliquot the COL4A5 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This COL4A5 antibody is available for research use only.
Storage Conditions
Aliquot the COL4A5 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05% sodium azide
Applications Notes
Optimal dilution of the COL4A5 antibody should be determined by the researcher.
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