Recombinant Stathmin 1 Antibody / STMN1

Stathmin 1 (Oncoprotein 18, STM1, prosolin or metablastin) is a conserved, Tubulin-associated, intracellular phosphoprotein. Many different phosphorylated forms of the protein are observed, and it is expressed as two different isoforms. Stathmin 1 is considered a critical regulator of microtubulin dynamics and is downregulated by p53. It serves as a transducing protein, via phophorylation, for a variety of cell signaling pathways and is involved in both mitosis and differentiation. It is present in many cancers, including breast carcinomas, and is highly expressed in acute leukemias of different subtypes.

Product Specifications

CAS Number

9000-83-3

Specifications

Immunohistochemistry (FFPE) : 1-2 µg/mL

UniProt

P16949

Host

Rabbit

Reactivity

Human

Immunogen

A recombinant fragment (within amino acids 1-148) of human STMN1 protein was used as the immunogen for the recombinant Stathmin 1 antibody.

Clonality

Recombinant Monoclonal

Isotype

IgG κ

Clone

STMN1/9227R

Type

Recombinant

Applications

IHC-P

Purity

Protein A/G affinity

Format

Purified

Buffer

0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide

Reconstitution

Aliquot the recombinant Stathmin 1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Limitations

This recombinant Stathmin 1 antibody is available for research use only.

Storage Conditions

Aliquot the recombinant Stathmin 1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Formulation

0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05% sodium azide

Applications Notes

Optimal dilution of the recombinant Stathmin 1 antibody should be determined by the researcher.

Location

Cytoplasm, Cytoskeleton

Image Legend

IHC staining of FFPE human colon carcinoma tissue with recombinant Stathmin 1 antibody (clone STMN1/9227R) . Inset: PBS used in place of primary Ab (secondary Ab negative control) . HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.