Oncoprotein 18 Antibody / OP18 / Stathmin 1
Op18 (for oncoprotein 18, also designated stathmin, prosolin or metablastin) is a conserved, Tubulin-associated, intracellular phosphoprotein. Many different phosphorylated forms of Op18 are observed, and it is expressed as two different isoforms. Op18 is considered a critical regulator of microtubulin dynamics and is downregulated by p53. It serves as a transducing protein, via phophorylation, for a variety of cell signaling pathways and is involved in both mitosis and differentiation.Op18 is present in many cancers, including breast carcinomas, and is highly expressed in acute leukemias of different subtypes.
Product Specifications
CAS Number
9007-83-4
Specifications
Immunohistochemistry (FFPE) : 1-2 µg/mL
UniProt
P16949
Host
Mouse
Reactivity
Human
Immunogen
A recombinant fragment of human Stathmin 1 protein was used as the immunogen for the Oncoprotein 18 antibody.
Clonality
Monoclonal
Isotype
IgG2b κ
Clone
STMN1/8439
Applications
IHC-P
Purity
Protein A/G affinity
Format
Purified
Buffer
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Reconstitution
Aliquot the Oncoprotein 18 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This Oncoprotein 18 antibody is available for research use only.
Storage Conditions
Aliquot the Oncoprotein 18 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05% sodium azide
Applications Notes
Optimal dilution of the Oncoprotein 18 antibody should be determined by the researcher.
Location
Cytoplasm, Cytoskeleton
Image Legend
Frequently Asked Questions
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