Stathmin 1 Antibody / STMN1
Stathmin 1 (Oncoprotein 18, STM1, prosolin or metablastin) is a conserved, Tubulin-associated, intracellular phosphoprotein. Many different phosphorylated forms of the protein are observed, and it is expressed as two different isoforms. Stathmin 1 is considered a critical regulator of microtubulin dynamics and is downregulated by p53. It serves as a transducing protein, via phophorylation, for a variety of cell signaling pathways and is involved in both mitosis and differentiation. It is present in many cancers, including breast carcinomas, and is highly expressed in acute leukemias of different subtypes.
Product Specifications
CAS Number
9007-83-4
Specifications
Immunohistochemistry (FFPE) : 1-2 µg/mL, Western blot: 2-4 µg/mL
UniProt
P16949
Host
Mouse
Reactivity
Human
Immunogen
A recombinant fragment of human STMN1 protein was used as the immunogen for the Stathmin 1 antibody.
Clonality
Monoclonal
Isotype
IgG1 k
Clone
STMN1/8437
Applications
IHC-P, WB
Purity
Protein A/G affinity
Format
Purified
Buffer
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Reconstitution
Aliquot the Stathmin 1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This Stathmin 1 antibody is available for research use only.
Storage Conditions
Aliquot the Stathmin 1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05% sodium azide
Applications Notes
Optimal dilution of the Stathmin 1 antibody should be determined by the researcher.
Location
Cytoplasm, Cytoskeleton
Image Legend
Western blot testing of human spleen tissue with Stathmin 1 antibody (clone STMN1/8437) . Predicted molecular weight ~17 kDa.
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