Recombinant STMN1 Antibody / Stathmin 1

Stathmin 1 (Oncoprotein 18, STM1, prosolin or metablastin) is a conserved, Tubulin-associated, intracellular phosphoprotein. Many different phosphorylated forms of the protein are observed, and it is expressed as two different isoforms. Stathmin 1 is considered a critical regulator of microtubulin dynamics and is downregulated by p53. It serves as a transducing protein, via phophorylation, for a variety of cell signaling pathways and is involved in both mitosis and differentiation. It is present in many cancers, including breast carcinomas, and is highly expressed in acute leukemias of different subtypes.

Product Specifications

CAS Number

9000-83-3

Specifications

Immunohistochemistry (FFPE) : 1-2 µg/mL

UniProt

P16949

Host

Mouse

Reactivity

Human

Immunogen

A recombinant fragment (within amino acids 1-148) of human STMN1 protein was used as the immunogen for the recombinant STMN1 antibody.

Clonality

Recombinant Monoclonal

Isotype

IgG2b κ

Clone

RSTMN1/9255

Type

Recombinant

Applications

IHC-P

Purity

Protein A/G affinity

Format

Purified

Buffer

0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide

Reconstitution

Aliquot the recombinant STMN1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Limitations

This recombinant STMN1 antibody is available for research use only.

Storage Conditions

Aliquot the recombinant STMN1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Formulation

0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05% sodium azide

Applications Notes

Optimal dilution of the recombinant STMN1 antibody should be determined by the researcher.

Location

Cytoplasm, Cytoskeleton

Image Legend

IHC staining of FFPE human colon carcinoma tissue with recombinant STMN1 antibody (clone rSTMN1/9255) . Inset: PBS used in place of primary Ab (secondary Ab negative control) . HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.