Recombinant TSHR beta Antibody / Thyroid Stimulating Hormone Receptor beta
Thyroid-stimulating hormone (TSH, also known as thyrotropin) is a glycoprotein involved in the control of thyroid structure and metabolism, which stimulates the release of the thyroid hormones. TSH is regulated by thyroid hormone (T3) and various retinoid compounds. TSH binds to the thyroid-stimulating hormone receptor (TSHR), which is cleaved into two subunits, A and B, and plays a major role in regulating thyroid function. The third cytoplasmic loop of TSHR has been identified as critical for its role in regulating inositol phosphate and cAMP formation. In Grave s disease, an autoimmune disorder, TSHR is activated by autoantibodies, which may be stimulated by the cleavage of the A and B subunits.
Product Specifications
CAS Number
9000-83-3
Specifications
Immunohistochemistry (FFPE) : 1-2 µg/mL
UniProt
P16473
Host
Rabbit
Reactivity
Human
Immunogen
A recombinant fragment (within amino acids 200-400) of human TSHR B-Chain protein was used as the immunogen for the recombinant TSHR beta antibody.
Clonality
Recombinant Monoclonal
Isotype
IgG κ
Clone
TSHRB/9215R
Type
Recombinant
Applications
IHC-P
Purity
Protein A/G affinity
Format
Purified
Buffer
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Reconstitution
Aliquot the recombinant TSHR beta antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This recombinant TSHR beta antibody is available for research use only.
Storage Conditions
Aliquot the recombinant TSHR beta antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05% sodium azide
Applications Notes
Optimal dilution of the recombinant TSHR beta antibody should be determined by the researcher.
Location
Cytoplasm, Cell membrane
Image Legend
SDS-PAGE analysis of purified recombinant TSHR beta antibody (clone TSHRB/9215R) as confirmation of integrity and purity.
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