Recombinant MUC1 Antibody / Mucin 1 / EMA
In Western blotting, it recognizes proteins in MW range of 265-400kDa, identified as different glycoforms of EMA/Mucin 1. The alpha subunit has cell adhesive properties. It can act both as an adhesion and an anti-adhesion protein. Mucin 1 may provide a protective layer on epithelial cells against bacterial and enzyme attack. The beta subunit contains a C-terminal domain, which is involved in cell signaling, through phosphorylations and protein-protein interactions. In immunohistochemical assays, it superbly stains routine formalin/paraffin carcinoma tissues. Antibody to EMA/Mucin 1 is useful as a pan-epithelial marker for detecting early metastatic loci of carcinoma in bone marrow or liver.
Product Specifications
CAS Number
9000-83-3
Specifications
Immunohistochemistry (FFPE) : 1-2 µg/mL
UniProt
P15941
Host
Mouse
Reactivity
Human
Immunogen
Recombinant full-length human Mucin 1 protein was used as the immunogen for the recombinant MUC1 antibody.
Clonality
Recombinant Monoclonal
Isotype
IgG2b κ
Clone
R115D8
Type
Recombinant
Applications
IHC-P
Purity
Protein A/G affinity
Format
Purified
Buffer
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Reconstitution
Aliquot the recombinant MUC1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This recombinant MUC1 antibody is available for research use only.
Storage Conditions
Aliquot the recombinant MUC1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05% sodium azide
Applications Notes
Optimal dilution of the recombinant MUC1 antibody should be determined by the researcher.
Location
Cytoplasm, Cell membrane
Image Legend
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