MYH7 Antibody / Myosin 7
Myosin heavy chains are ubiquitous Actin-based motor proteins that convert the chemical energy derived from ATP hydrolysis into the mechanical energy that drives diverse motile processes in eukaryotic cells, including cytokinesis, vesicular transport and cellular locomotion. Muscle myosin is a heterohexamer consisting of two myosin heavy chains and two associated nonidentical pairs of myosin light chains. The seven myosin heavy chain isoforms that predominate in mammalian skeletal muscles include two developmental isoforms, MHC-embryonic (MYH3) and MHC-perinatal (MYH8) ; three adult skeletal muscle isoforms, MHC IIa (MYH2), MHC IIb (MYH4) and MHC IIx/d (MYH1) ; and MHC-?/slow (MYH7 or MHC-?), which is also expressed in cardiac muscle. Research indicates that mutations of the MYH7 gene causes hypertrophic cardiomyopathy.
Product Specifications
CAS Number
9007-83-4
Specifications
Immunohistochemistry (FFPE) : 1-2 µg/mL
UniProt
P12883
Host
Mouse
Reactivity
Human
Immunogen
A recombinant fragment (within amino acids 1150-1350) of human Myosin 7 protein was used as the immunogen for the MYH7 antibody.
Clonality
Monoclonal
Isotype
IgG2b κ
Clone
MYH7/9183
Applications
IHC-P
Purity
Protein A/G affinity
Format
Purified
Buffer
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Reconstitution
Aliquot the MYH7 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This MYH7 antibody is available for research use only.
Storage Conditions
Aliquot the MYH7 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05% sodium azide
Applications Notes
Optimal dilution of the MYH7 antibody should be determined by the researcher.
Location
Cytoplasm
Image Legend
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