SI-113

SI-113 is a SGK1 inhibitor, with an IC50 of 600 nM. SI113 induces autophagy[1][2].

Product Specifications

CAS Number

[1392816-46-4]

Product Name Alternative

(+)-Bicuculline (methobromide); d-Bicuculline (methobromide)

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

SGK

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/si-113.html

Purity

98.02

Solubility

DMSO : 250 mg/mL (ultrasonic)

Smiles

OCCNC1=NC(NCCC2=CC=CC=C2)=C3C(N(/C=C/C4=CC=CC=C4)N=C3)=N1

Molecular Formula

C23H24N6O

Molecular Weight

400.48

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Marco Radi , et al. A combined targeted/phenotypic approach for the identification of new antiangiogenics agents active on a zebrafish model: from in silico screening to cyclodextrin formulation. Bioorg Med Chem Lett. 2012 Sep 1;22 (17) :5579-83.|[2]Silvia Matteoni, et al. The kinase inhibitor SI113 induces autophagy and synergizes with quinacrine in hindering the growth of human glioblastoma multiforme cells. J Exp Clin Cancer Res. 2019 May 17;38 (1) :202.