Mepivacaine

Mepivacaine is an amide-type local anesthetic agent. Mepivacaine binds to specific voltage-gated sodium ion channels in neuronal cell membranes, which inhibits both sodium influx and membrane depolarization[1][2].

Product Specifications

CAS Number

[96-88-8]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Sodium Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/mepivacaine.html

Concentration

10mM

Purity

98.10

Solubility

DMSO : 33.33 mg/mL (ultrasonic)

Smiles

O=C(C(CCCC1)N1C)NC(C(C)=CC=C2)=C2C

Molecular Formula

C15H22N2O

Molecular Weight

246.35

Precautions

H302, H315, H319, H335

References & Citations

[1]Froehle M, et al. ECMO for Cardiac Rescue after Accidental Intravenous Mepivacaine Application. Case Rep Pediatr. 2012;2012:491692.|[2]mepivacaine hydrochloride.|[3]Burm, A.G., et al., Pharmacokinetics of the enantiomers of mepivacaine after intravenous administration of the racemate in volunteers. Anesth Analg, 1997. 84 (1) : p. 85-9.|[4]Leffler, A., J. Reckzeh, and C. Nau, Block of sensory neuronal Na+ channels by the secreolytic ambroxol is associated with an interaction with local anesthetic binding sites. Eur J Pharmacol, 2010. 630 (1-3) : p. 19-28.