CCNH Antibody / Cyclin H
Regulates CDK7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throughout the cell cycle. [UniProt]
Product Specifications
CAS Number
9000-83-3
Specifications
Western blot: 1:500-1:2000
UniProt
P51946
Host
Rabbit
Reactivity
Human
Immunogen
A synthetic peptide derived from human Cyclin H/p34 was used as the immunogen for the CCNH antibody.
Clonality
Recombinant Monoclonal
Isotype
IgG
Clone
28C49
Type
Recombinant
Applications
WB
Purity
Affinity chromatography
Format
Purified
Buffer
Antibody in PBS with 0.02% sodium azide, 50% glycerol and 0.4-0.5mg/ml BSA
Reconstitution
Store the CCNH antibody at -20oC.
Limitations
This CCNH antibody is available for research use only.
Storage Conditions
Store the CCNH antibody at -20°C.
Formulation
Antibody in PBS with 0.02% sodium azide, 50% glycerol and 0.4-0.5 mg/mL BSA
Applications Notes
Optimal dilution of the CCNH antibody should be determined by the researcher.
Image Legend
Western blot testing of human A431 cell lysate with CCNH antibody. Predicted molecular weight ~38 kDa.
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