P4HTM Antibody / HIF Prolyl Hydroxylases / HIFPH4
Catalyzes the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates HIF1A at 'Pro-402' and 'Pro-564'. May function as a cellular oxygen sensor and, under normoxic conditions, may target HIF through the hydroxylation for proteasomal degradation via the von Hippel-Lindau ubiquitination complex. [UniProt]
Product Specifications
CAS Number
9000-83-3
Specifications
Western blot: 1:500-1:2000
UniProt
Q9NXG6
Host
Rabbit
Reactivity
Human
Immunogen
A synthetic peptide derived from human HIF Prolyl Hydroxylases was used as the immunogen for the P4HTM antibody.
Clonality
Recombinant Monoclonal
Isotype
IgG
Clone
28P22
Type
Recombinant
Applications
WB
Purity
Affinity chromatography
Format
Purified
Buffer
Antibody in PBS with 0.02% sodium azide, 50% glycerol and 0.4-0.5mg/ml BSA
Reconstitution
Store the P4HTM antibody at -20oC.
Limitations
This P4HTM antibody is available for research use only.
Storage Conditions
Store the P4HTM antibody at -20°C.
Formulation
Antibody in PBS with 0.02% sodium azide, 50% glycerol and 0.4-0.5 mg/mL BSA
Applications Notes
Optimal dilution of the P4HTM antibody should be determined by the researcher.
Image Legend
Western blot testing of human HeLa cell lysate with P4HTM antibody. Predicted molecular weight: 47-63 kDa (three isoforms) .
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