PRPF8 Antibody / Pre-mRNA-processing-splicing factor 8
Pre-mRNA-processing-splicing factor 8 is a protein that in humans is encoded by the PRPF8 gene. Pre-mRNA splicing occurs in 2 sequential transesterification steps. The protein encoded by this gene is a component of both U2- and U12-dependent spliceosomes, and found to be essential for the catalytic step II in pre-mRNA splicing process. It contains several WD repeats, which function in protein-protein interactions. This protein has a sequence similarity to yeast Prp8 protein. This gene is a candidate gene for autosomal dominant retinitis pigmentosa.
Product Specifications
CAS Number
9007-83-4
Specifications
Western blot: 0.5-1 µg/mL, Direct ELISA: 0.1-0.5 µg/mL
UniProt
Q6P2Q9
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
E. coli-derived recombinant human protein (amino acids E433-H2166) was used as the immunogen for the PRPF8 antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB, Direct ELISA
Purity
Antigen affinity purified
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2% Trehalose
Reconstitution
Limitations
This PRPF8 antibody is available for research use only.
Storage Conditions
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
Optimal dilution of the PRPF8 antibody should be determined by the researcher.
Image Legend
Western blot testing of 1) human HeLa, 2) human SH-SY5Y and 3) mouse NIH 3T3 cell lysate with PRPF8 antibody. Predicted molecular weight ~274 kDa.
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