Denudatine

Denudatine, is primarily isolated from plants of the genera Aconitum and Delphinium[1]. Denudatine has effects on action potential of ventricular fibers and inhibits arrhythmogenic action of aconitine[2].

Product Specifications

CAS Number

[26166-37-0]

UNSPSC

12352005

Hazard Statement

H301

Target

Others

Type

Natural Products

Related Pathways

Others

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/denudatine.html

Solubility

10 mM in DMSO

Smiles

O[C@@H]([C@]1([H])CC2)[C@@]3([H])C([C@@]4([H])C5)(CCCC4(C)CN6CC)[C@@]6([H])[C@@]5([H])[C@]32[C@H](O)C1=C

Molecular Formula

C22H33NO2

Molecular Weight

343.50

Precautions

P264-P270-P330-P405-P501

References & Citations

[1]Nishiyama Y, et al. Synthesis of Cardiopetaline via a Wagner-Meerwein Rearrangement without Preactivation of the Pivotal Hydroxy Group. Org Lett. 2017 Nov 3;19 (21) :5833-5835.|[2]Liu TF, et al. Effects of denudatine on action potential of ventricular fibers and its inhibition on arrhythmogenic action of aconitine (author's transl) . Zhongguo Yao Li Xue Bao. 1982 Mar;3 (1) :32-4.