NLRP3-IN-58
NLRP3-IN-58 (Compound DS15) is an inhibitor for the activation of NLRP3 inflammasome with an IC50 of 3.85 μM, and inhibits 33% IL-1β release at a concentration of 10 μM[1].
Product Specifications
CAS Number
2956014-05-2
UNSPSC
12352101
Target
Interleukin Related; NOD-like Receptor (NLR)
Type
Reference compound
Related Pathways
Immunology/Inflammation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/nlrp3-in-58.html
Smiles
O=C(NC1=CC=CC(S(=O)(NC2=CC=CC=C2)=O)=C1)CC3=CNC4=CC(Cl)=CC=C34
Molecular Formula
C22H18ClN3O3S
Molecular Weight
439.91
References & Citations
[1]El-Sayed S, et al., Virtual screening-led design of inhibitor scaffolds for the NLRP3 inflammasome. Bioorg Chem. 2024 Oct 22;153:107909.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
BNC551037-500 1x 500 µL
CD44 Standard (DF1485), CF555 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC881133-100 1x 100 µL
CD74 (CLIP/1133), CF488A conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC882747-100 1x 100 µL
TCL1 (T-Cell Marker) (TCL1/2747R), CF488A conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC040756-100 1x 100 µL
Neurofilament (H+L) (NF421 + NFL736), CF405S conjugate, 0.1mg/mL
Sign In for Pricing
View Details