Hexamethonium (Bromide)

Hexamethonium Bromide is a non-selective ganglionic nicotinic-receptor antagonist (nAChR) antagonist, with mixed competitive and noncompetitive activity. Hexamethonium Bromide has anti-hypertensive activity. Hexamethonium Bromide attenuates sympathetic activity and blood pressure in spontaneously hypertensive animal models[1][2][3][4].

Product Specifications

CAS Number

[55-97-0]

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis; nAChR

Type

Reference compound

Related Pathways

Apoptosis; Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/hexamethonium-bromide.html

Purity

99.91

Solubility

DMSO : 16.67 mg/mL (ultrasonic) |H2O : ≥ 100 mg/mL

Smiles

C[N+](C)(C)CCCCCC[N+](C)(C)C.[Br-].[Br-]

Molecular Formula

C12H30Br2N2

Molecular Weight

362.19

Precautions

H302, H315, H319, H335

References & Citations

[1]Damian J. Williams, et al. Mechanisms involved in nicotinic acetylcholine receptor-induced neurotransmitter release from sympathetic nerve terminals in the mouse vas deferens. PLoS One. 2011; 6 (12) : e29209.|[2]Roger L. Papke, et al. Activation and Inhibition of Mouse Muscle and Neuronal Nicotinic Acetylcholine Receptors Expressed in Xenopus Oocytes. J Pharmacol Exp Ther. 2010 May; 333 (2) : 501–518.|[3]Brian T Hawkins, et al. Modulation of cerebral microvascular permeability by endothelial nicotinic acetylcholine receptors. Am J Physiol Heart Circ Physiol. 2005 Jul;289 (1) :H212-9.|[4]Peng Li, et al. Hexamethonium attenuates sympathetic activity and blood pressure in spontaneously hypertensive rats. Mol Med Rep. 2015 Nov;12 (5) :7116-22.