Myristicin
Product Specifications
UNSPSC Description
Myristicine is an orally bioavailable serotonin receptor antagonist and weak monoamine oxidase (MAO) inhibitor. Myristicine also exerts anti-cancer effects on gastric cancer cells by inhibiting the EGFR/ERK signaling pathway. Myristicine is the main component of nutmeg essential oil and has anti-cancer, anti-proliferative, antibacterial, anti-inflammatory and apoptosis-inducing effects. Myristicine abuse can produce hallucinogenic effects, organ damage, etc[1][2][3][4].
Target Antigen
5-HT Receptor; Apoptosis; Bacterial; EGFR; ERK
Type
Natural Products
Related Pathways
Anti-infection;Apoptosis;GPCR/G Protein;JAK/STAT Signaling;MAPK/ERK Pathway;Neuronal Signaling;Protein Tyrosine Kinase/RTK;Stem Cell/Wnt
Applications
Neuroscience-Neuromodulation
Field of Research
Cancer; Infection; Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/myristicin.html
Purity
99.89
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
C=CCC1=CC(OC)=C2OCOC2=C1
Molecular Weight
192.21
References & Citations
[1]Kalbhen DA, et al. Nutmeg as a narcotic. A contribution to the chemistry and pharmacology of nutmeg (Myristica fragrans).Angew Chem Int Ed Engl. 1971 Jun;10(6):370-4.|[2]Dawidowicz AL, et al. Simple and rapid determination of myristicin in human serum.Forensic Toxicol. 2013 Jan;31(1):119-123. Epub 2012 Aug 15.|[3]Badr G, Elsawy H, Amalki M A, et al. Protective effects of myristicin against ulcerative colitis induced by acetic acid in male mice[J]. Food and Agricultural Immunology, 2020, 31(1): 435-446.|[4]Song J, et al. Myristicin Suppresses Gastric Cancer Growth via Targeting the EGFR/ ERK Signaling Pathway. Curr Mol Pharmacol. 2023;16(7):712-724.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, stored under nitrogen)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-N2510/Myristicin-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-N2510/Myristicin-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
607-91-0
Available Sizes
Curated Selection
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