Myristicin

Myristicine is an orally bioavailable serotonin receptor antagonist and weak monoamine oxidase (MAO) inhibitor. Myristicine also exerts anti-cancer effects on gastric cancer cells by inhibiting the EGFR/ERK signaling pathway. Myristicine is the main component of nutmeg essential oil and has anti-cancer, anti-proliferative, antibacterial, anti-inflammatory and apoptosis-inducing effects. Myristicine abuse can produce hallucinogenic effects, organ damage, etc[1][2][3][4].

Product Specifications

CAS Number

[607-91-0]

Product Name Alternative

Myristicine

UNSPSC

12352005

Hazard Statement

H361, H412

Target

5-HT Receptor; Apoptosis; Bacterial; EGFR; ERK

Type

Natural Products

Related Pathways

Anti-infection; Apoptosis; GPCR/G Protein; JAK/STAT Signaling; MAPK/ERK Pathway; Neuronal Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt

Applications

Neuroscience-Neuromodulation

Field of Research

Cancer; Infection; Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/myristicin.html

Purity

99.89

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

C=CCC1=CC(OC)=C2OCOC2=C1

Molecular Formula

C11H12O3

Molecular Weight

192.21

Precautions

H361, H412

References & Citations

[1]Kalbhen DA, et al. Nutmeg as a narcotic. A contribution to the chemistry and pharmacology of nutmeg (Myristica fragrans) .Angew Chem Int Ed Engl. 1971 Jun;10 (6) :370-4.|[2]Dawidowicz AL, et al. Simple and rapid determination of myristicin in human serum.Forensic Toxicol. 2013 Jan;31 (1) :119-123. Epub 2012 Aug 15.|[3]Badr G, Elsawy H, Amalki M A, et al. Protective effects of myristicin against ulcerative colitis induced by acetic acid in male mice[J]. Food and Agricultural Immunology, 2020, 31 (1) : 435-446.|[4]Song J, et al. Myristicin Suppresses Gastric Cancer Growth via Targeting the EGFR/ ERK Signaling Pathway. Curr Mol Pharmacol. 2023;16 (7) :712-724.