Aβ-IN-10

Aβ-IN-10 (Compound Alz -5) is a bifunctional copper chelator and an inhibitor for beta-amyloid (Aβ), that interacts with Aβ aggregates and reduces the neurotoxicity. Aβ-IN-10 exhibits antioxidant efficacy, reveals moderate cytotoxicity with the presence of CuCl2 in SH-SY5Y and HepG2 with IC50 of 65.5, 31.2 μM. Aβ-IN-10 reduces the increase of cell stiffness caused by Aβ[1].

Product Specifications

UNSPSC

12352211

Target

Amyloid-β

Type

Reference compound

Related Pathways

Neuronal Signaling

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/aβ-in-10.html

Smiles

CC(/C(C)=N/NC(NC1=CC=C(/C=C/C2=CC=C(N(C)C)C=C2)C=C1)=S)=N\NC(NCCC3=CC=CC=C3)=S

Molecular Formula

C30H35N7S2

Molecular Weight

557.78

References & Citations

[1]Krasnovskaya O, et al., Bifunctional Copper Chelators Capable of Reducing Aβ Aggregation and Aβ-Induced Oxidative Stress. ACS Omega. 2024 Oct 17;9 (43) :43376-43384.