Aβ-IN-10
Aβ-IN-10 (Compound Alz -5) is a bifunctional copper chelator and an inhibitor for beta-amyloid (Aβ), that interacts with Aβ aggregates and reduces the neurotoxicity. Aβ-IN-10 exhibits antioxidant efficacy, reveals moderate cytotoxicity with the presence of CuCl2 in SH-SY5Y and HepG2 with IC50 of 65.5, 31.2 μM. Aβ-IN-10 reduces the increase of cell stiffness caused by Aβ[1].
Product Specifications
UNSPSC
12352211
Target
Amyloid-β
Type
Reference compound
Related Pathways
Neuronal Signaling
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/aβ-in-10.html
Smiles
CC(/C(C)=N/NC(NC1=CC=C(/C=C/C2=CC=C(N(C)C)C=C2)C=C1)=S)=N\NC(NCCC3=CC=CC=C3)=S
Molecular Formula
C30H35N7S2
Molecular Weight
557.78
References & Citations
[1]Krasnovskaya O, et al., Bifunctional Copper Chelators Capable of Reducing Aβ Aggregation and Aβ-Induced Oxidative Stress. ACS Omega. 2024 Oct 17;9 (43) :43376-43384.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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