Tityustoxin Kα

<strong>Tityustoxin Kα</strong> <strong>Catalog number:</strong> MDP0682 <strong>CAS Number: </strong>209005-05-0 <strong>Sequence: </strong>Val-Phe-Ile-Asn-Ala-Lys-Cys-Arg-Gly-Ser-Pro-Glu-Cys-Leu-Pro-Lys-Cys-Lys-Glu-Ala-Ile-Gly-Lys-Ala-Ala-Gly-Lys-Cys-Met-Asn-Gly-Lys-Cys-Lys-Cys-Tyr-Pro (Reported disulfide bonds between Cys7-Cys28, Cys13-Cys33, and Cys17-Cys35) <strong>Amount:</strong> 100 ug <strong>Molecular Weight:</strong> 3941.6 g/mol <strong>Supplied as:</strong> Powder <strong>Applications:</strong> molecular tool for various biochemical applications <strong>Storage:</strong> -20 °C <strong>WARNING:</strong> For in vitro Research Use Only. NOT for use on humans or animals. <strong>Grade:</strong> Biotechnology grade. All products are highly pure. <strong>References:</strong> 1: Sitges M, Galindo CA. Omega-agatoxin-TK is a useful tool to study P-type Ca2+ channel-mediated changes in internal Ca2+ and glutamate release in depolarised brain nerve terminals Neurochem Int. 2005 Jan;46(1):53-60. 2: Kuwada M, Teramoto T, Kumagaye KY, Nakajima K, Watanabe T, Kawai T, Kawakami Y, Niidome T, Sawada K, Nishizawa Y, et al. Omega-agatoxin-TK containing D-serine at position 46, but not synthetic omega-[L-Ser46]agatoxin-TK, exerts blockade of P-type calcium channels in cerebellar Purkinje neurons Mol Pharmacol. 1994 Oct;46(4):587-93. 3: Teramoto T, Niidome T, Kimura M, Ohgoh M, Nishizawa Y, Katayama K, Mayumi T, Sawada K. A novel type of calcium channel sensitive to omega-agatoxin-TK in cultured rat cerebral cortical neurons Brain Res. 1997 May 9;756(1-2):225-30. 4: Barral J, Poblette F, Mendoza E, Pineda JC, Galarraga E, Bargas J. High-affinity inhibition of glutamate release from corticostriatal synapses by omega-agatoxin TK Eur J Pharmacol. 2001 Nov 2;430(2-3):167-73. 5: Vázquez-Vázquez H, Gonzalez-Sandoval C, Vega AV, Arias-Montaño JA, Barral J. Histamine H(3) Receptor Activation Modulates Glutamate Release in the Corticostriatal Synapse by Acting at Ca(V)2.1 (P/Q-Type) Calcium Channels and GIRK (K(IR)3) Potassium Channels Cell Mol Neurobiol. 2022 Apr;42(3):817-828. 6: Andrews DA, Yang L, Low PS. Phorbol ester stimulates a protein kinase C-mediated agatoxin-TK-sensitive calcium permeability pathway in human red blood cells Blood. 2002 Nov 1;100(9):3392-9. 7: Teramoto T, Niidome T, Miyagawa T, Nishizawa Y, Katayama K, Sawada K. Two types of calcium channels sensitive to omega-agatoxin- TK in cultured rat hippocampal neurones Neuroreport. 1995 Aug 21;6(12):1684-8. 8: Jansen J, Qiao M, Hertz L, Wang X, Fermo E, Zaninoni A, Colombatti R, Bernhardt I, Bianchi P, Kaestner L. Mechanistic ion channel interactions in red cells of patients with Gárdos channelopathy Blood Adv. 2021 Sep 14;5(17):3303-3308. 9: Nishijo T, Suzuki E, Momiyama T. Serotonin 5-HT(1A) and 5-HT(1B) receptor-mediated inhibition of glutamatergic transmission onto rat basal forebrain cholinergic neurones J Physiol. 2022 Jul;600(13):3149-3167. <a href="https://pubmed.ncbi.nlm.nih.gov/10220411">10: Vogel SS, Smith RM, Baibakov B, Ikebuchi Y, Lambert NA. Calcium influx is required for endocytotic membrane retrieval Proc Natl Acad Sci U S A. 1999 Apr 27;96(9):5019-24. </a> <br><strong>Products Related to Tityustoxin Kα can be found at</strong> <a href="https://moleculardepot.com/product-category/Peptides/"> Peptides</a>